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MAdCAM-1 Antibody (CA 102.2C1)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-63277

Novus Biologicals, part of Bio-Techne
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NB100-63277

Key Product Details

Species Reactivity

Human

Applications

ELISA, Functional, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CA 102.2C1

Concentration

1.0 mg/ml

Product Specifications

Immunogen

Bacterially expressed human MAdCAM-1

Localization

Membrane; single pass type I membrane protein.

Specificity

NB100-63277 recognizes human MAdCAM-1 (mucosal addressin cell adhesion molecule -1), a 40kD protein expressed by vascular endothelium. Clone CA102.2C1 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for MAdCAM-1 Antibody (CA 102.2C1)

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

No Preservative

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MAdCAM-1

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM1 (alpha4 beta7), L selectin, and VLA4 (alpha4 beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full length nature of some variants has not been determined.

Long Name

Mucosal Addressin Cell Adhesion Molecule 1

Alternate Names

MAdCAM1

Entrez Gene IDs

8174 (Human)

Gene Symbol

MADCAM1

UniProt

Additional MAdCAM-1 Products

Product Documents for MAdCAM-1 Antibody (CA 102.2C1)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MAdCAM-1 Antibody (CA 102.2C1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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