MAML2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2127

Novus Biologicals, part of Bio-Techne
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NB100-2127
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Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all MAML2 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1100 and the C-terminus (residue 1153) of human Mastermind-Like 2 using the numbering given in entry AAK93831.1 (GeneID 84441).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAML2 Antibody

Western Blot: MAML2 Antibody [NB100-2127]

Western Blot: MAML2 Antibody [NB100-2127]

Western Blot: MAML2 Antibody [NB100-2127] - Detection of Human and Mouse MAML2 on HeLa whole cell lysate using NB100-2127. MAML2 was also immunoprecipitated by another rabbit anti-MAML2 antibodies and NB100-2126.
Immunohistochemistry-Paraffin: MAML2 Antibody [NB100-2127]

Immunohistochemistry-Paraffin: MAML2 Antibody [NB100-2127]

Immunohistochemistry-Paraffin: MAML2 Antibody [NB100-2127] - Human breast carcinoma. Antibody: Affinity purified rabbit anti-MAML2 used at a dilution of 1:200 (1ug/ml). Detection: DAB

Applications for MAML2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:1000

Immunohistochemistry-Paraffin

1:200 - 1:1000

Immunoprecipitation

1-4 ug/mg of lysate

Western Blot

1:2000-1:15000
Application Notes
Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: MAML2

There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis. Alternate names for MAML2 include Mam-2, MAM2, MAM3, MAM-3, MLL-MAML2, MGC176701, DKFZp686N0150, and KIAA1819.

Alternate Names

DKFZp686N0150, KIAA1819MGC176701, MAM2, Mam-2, MAM-3, MAM3MLL-MAML2, mastermind (Drosophila)-like 2, mastermind-like 2 (Drosophila), mastermind-like protein 2

Entrez Gene IDs

84441 (Human); 270118 (Mouse)

Gene Symbol

MAML2

UniProt

AAK93831.1 (Human)

Additional MAML2 Products

Product Documents for MAML2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MAML2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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