MARCH2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-21582

Novus Biologicals, part of Bio-Techne
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NBP2-21582
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MARCH2 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human MARCH2. The exact sequence is proprietary.

Reactivity Notes

Immunogen shows the following sequence identity with these species: Mouse (94%), Rat (94%), Porcine (95%), Bovine (91%), Zebrafish (81%), Xenopus laevis (80%).

Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein; Lysosome membrane; Multi-pass membrane protein; Endosome membrane; Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MARCH2 Antibody

Western Blot: MARCH2 Antibody [NBP2-21582]

Western Blot: MARCH2 Antibody [NBP2-21582]

Western Blot: MARCH2 Antibody [NBP2-21582] - Sample (30 ug of whole cell lysate) A: HepG2 membrane 12% SDS PAGE gel, diluted at 1:5000.

Applications for MARCH2 Antibody

Application
Recommended Usage

Western Blot

1:1000-1:10000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: MARCH2

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM]

Alternate Names

EC 6.3.2, EC 6.3.2.-, MARCH-IIHSPC240, membrane-associated ring finger (C3HC4) 2, Membrane-associated RING finger protein 2, Membrane-associated RING-CH protein II, RING finger protein 172, RNF172E3 ubiquitin-protein ligase MARCH2

Gene Symbol

MARCH2

UniProt

Q9P0N8 (Human)

Additional MARCH2 Products

Product Documents for MARCH2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MARCH2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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