Maxi Potassium channel beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-33484

Novus Biologicals, part of Bio-Techne
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NBP1-33484
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Rat

Predicted:

Rhesus Macaque (94%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Maxi Potassium channel beta Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human Maxi Potassium channel beta. The exact sequence is proprietary.

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 27165430). Dog (84%), Rabbit (85%), Bovine (84%).

Localization

Membrane, Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Maxi Potassium channel beta Antibody

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484]

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484]

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 12% SDS PAGE; antibody diluted at 1:1000.
Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484]

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484]

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (50 ug of whole cell lysate) A: mouse heart 12% SDS PAGE; antibody diluted at 1:10000.

Applications for Maxi Potassium channel beta Antibody

Application
Recommended Usage

Western Blot

1:1000-1:10000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Maxi Potassium channel beta

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Long Name

Calcium-activated potassium channel subunit beta-1

Alternate Names

BKbeta, BKbeta1, Hbeta1, K(VCA)beta-1, KCNMB1, Slo-beta, Slo-beta-1

Gene Symbol

KCNMB1

Additional Maxi Potassium channel beta Products

Product Documents for Maxi Potassium channel beta Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Maxi Potassium channel beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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