Maxi Potassium channel beta Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-03655

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Maxi Potassium channel beta Antibodies »

Product Specifications

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human Maxi Potassium channel beta (NP_004128.1). TYYILVTTVLPLYQKSVWTQESKCHLIETNIRDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Maxi Potassium channel beta Antibody - BSA Free

Western Blot: Maxi Potassium channel beta AntibodyBSA Free [NBP3-03655]

Western Blot: Maxi Potassium channel beta AntibodyBSA Free [NBP3-03655]

Western Blot: Maxi Potassium channel beta Antibody [NBP3-03655] - Analysis of extracts of various cell lines, using Maxi Potassium channel beta antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST

Applications for Maxi Potassium channel beta Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:200-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS with 50% glycerol, pH7.3.

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Maxi Potassium channel beta

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Long Name

Calcium-activated potassium channel subunit beta-1

Alternate Names

BKbeta, BKbeta1, Hbeta1, K(VCA)beta-1, KCNMB1, Slo-beta, Slo-beta-1

Gene Symbol

KCNMB1

Additional Maxi Potassium channel beta Products

Product Documents for Maxi Potassium channel beta Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Maxi Potassium channel beta Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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