MBL-2 Antibody (16A8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51146

Novus Biologicals, part of Bio-Techne
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NBP1-51146
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Key Product Details

Species Reactivity

Mouse

Applications

Immunoassay, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # 16A8

Concentration

0.1 mg/ml

View all MBL-2 Antibodies »

Product Specifications

Immunogen

MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for MBL-2 Antibody (16A8)

Application
Recommended Usage

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.2 um filtered solution in PBS and 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: MBL-2

Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A. The monoclonal antibody 16A8 is a calcium-dependent antibody.

Long Name

Mannose Binding Lectin 2

Alternate Names

L-MBP, MBL-C

Gene Symbol

Mbl2

Additional MBL-2 Products

Product Documents for MBL-2 Antibody (16A8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MBL-2 Antibody (16A8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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