MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Long Name

Double Minute 2 Protein

Alternate Names

HDM2

Gene Symbol

MDM2

Additional MDM2/HDM2 Products

Product Documents for MDM2/HDM2 Antibody (MDM2/7061R) [Janelia Fluor® 635]

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Product Specific Notices for MDM2/HDM2 Antibody (MDM2/7061R) [Janelia Fluor® 635]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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MDM2/HDM2 Antibody (MDM2/7061R) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14119JF635

Key Product Details

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Applications for MDM2/HDM2 Antibody (MDM2/7061R) [Janelia Fluor® 635]

ELISA

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Background: MDM2/HDM2