MDM2/HDM2 Antibody (rMDM2/9214) [Janelia Fluor® 585]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24198JF585

Submit a review

Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-23760

Alexa Fluor 350

NBP3-24198AF350

Alexa Fluor 405

NBP3-24198AF405

Alexa Fluor 488

NBP3-24198AF488

Alexa Fluor 532

NBP3-24198AF532

Alexa Fluor 594

NBP3-24198AF594

Alexa Fluor 647

NBP3-24198AF647

Alexa Fluor 700

NBP3-24198AF700

Alexa Fluor 750

NBP3-24198AF750

Allophycocyanin

NBP3-24198APC

Biotin

NBP3-24198B

CoraFluor 1

NBP3-24198CL1

DyLight 350

NBP3-24198UV

DyLight 405

NBP3-24198V

DyLight 488

NBP3-24198G

DyLight 550

NBP3-24198R

DyLight 594

NBP3-24198DL594

DyLight 650

NBP3-24198C

DyLight 680

NBP3-24198FR

DyLight 755

NBP3-24198IR

FITC

NBP3-24198F

HRP

NBP3-24198H

Janelia Fluor 525

NBP3-24198JF525

Janelia Fluor 549

NBP3-24198JF549

Janelia Fluor 635

NBP3-24198JF635

Janelia Fluor 646

NBP3-24198JF646

Janelia Fluor 669

NBP3-24198JF669

mFluor Violet 450 SE

NBP3-24198MFV450

mFluor Violet 500 SE

NBP3-24198MFV500

mFluor Violet 610 SE

NBP3-24198MFV610

PE

NBP3-24198PE

PerCP

NBP3-24198PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-24198

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Janelia Fluor 585

Antibody Source

Recombinant Monoclonal Mouse IgG2b Kappa Clone # rMDM2/9214

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MDM2/HDM2 Antibodies »

Product Specifications

Immunogen

Recombinant human MDM2/HDM2 protein fragment (exact sequence is proprietary)

Localization

Nucleus.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for MDM2/HDM2 Antibody (rMDM2/9214) [Janelia Fluor® 585]

Application

Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: MDM2/HDM2

MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Long Name

Double Minute 2 Protein

Alternate Names

HDM2

Gene Symbol

MDM2

Additional MDM2/HDM2 Products

Product Documents for MDM2/HDM2 Antibody (rMDM2/9214) [Janelia Fluor® 585]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for MDM2/HDM2 Antibody (rMDM2/9214) [Janelia Fluor® 585]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews