MeCP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB600-1101

Novus Biologicals, part of Bio-Techne
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NB600-1101
NB600-1101-25ug
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Rat

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all MeCP2 Antibodies »

Product Specifications

Immunogen

Synthetic Peptide: M(1) V A G M L G L R E E K S E D(15) C

Localization

Nuclear

Specificity

This detects methyl CpG binding protein 2 (MeCP2) from human, mouse and rat tissues and cells.

Marker

Nucleus Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MeCP2 Antibody

Western Blot: MeCP2 Antibody [NB600-1101]

Western Blot: MeCP2 Antibody [NB600-1101]

Western Blot: MeCP2 Antibody [NB600-1101] - Analysis of HeLa cell extract.
Immunocytochemistry/ Immunofluorescence: MeCP2 Antibody [NB600-1101]

Immunocytochemistry/ Immunofluorescence: MeCP2 Antibody [NB600-1101]

Immunocytochemistry/Immunofluorescence: MeCP2 Antibody [NB600-1101] - Analysis of Methyl CpG Binding Protein 2 (green) showing staining in the nucleus of C2C12 cells (right) compared to a negative control without primary antibody (left).
Immunohistochemistry-Paraffin: MeCP2 Antibody [NB600-1101]

Immunohistochemistry-Paraffin: MeCP2 Antibody [NB600-1101]

Immunohistochemistry-Paraffin: MeCP2 Antibody [NB600-1101] - Staining in the nucleus of rat brain tissue (right) compared to a negative control without primary antibody (left).
View 1 more images

Applications for MeCP2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100 - 1:200

Immunohistochemistry

1:200 - 1:2000

Immunohistochemistry-Paraffin

1:200 - 1:2000

Immunoprecipitation

1:10 - 1:500

Western Blot

0.5 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MeCP2

DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X-chromosome inactivation. Methyl CpG binding proteins (MeCPs) specifically recognize methylated regions of DNA and repress transcription both directly and by association with known corepressor proteins which include members of the Sin3 and histone deactylase protein families.

Alternate Names

AUTSX3, DKFZp686A24160, MeCp-2 protein, mental retardation, X-linked 79, methyl CpG binding protein 2 (Rett syndrome), X-linked 16

Entrez Gene IDs

4204 (Human); 17257 (Mouse); 29386 (Rat)

Gene Symbol

MECP2

UniProt

P51608 (Human)

Additional MeCP2 Products

Product Documents for MeCP2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MeCP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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