MLK3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-06619

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MLK3 Antibodies »

Product Specifications

Immunogen

Produced in rabbits immunized with E. coli-derived Human MLK3 fragment.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for MLK3 Antibody

Immunohistochemistry: MLK3 Antibody [NBP3-06619]

Immunohistochemistry: MLK3 Antibody [NBP3-06619]

Immunohistochemistry: MLK3 Antibody [NBP3-06619] - Immunohistochemical staining of human MLK3 in human liver with NBP3-06619 at 1:100 dilution, formalin-fixed paraffin embedded sections.
Immunohistochemistry: MLK3 Antibody [NBP3-06619]

Immunohistochemistry: MLK3 Antibody [NBP3-06619]

Immunohistochemistry: MLK3 Antibody [NBP3-06619] - Immunohistochemical staining of human MLK3 in human kidney with NBP3-06619 at 1:100 dilution, formalin-fixed paraffin embedded sections.

Applications for MLK3 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:50-1:200

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

PBS

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MLK3

Mixed lineage kinase-3 (MLK-3) is a mitogen-activated kinase kinase kinase that mediates stress-activating protein kinase (SAPK)/c-Jun NH2-terminal kinase activation. MLK-3 and other MLK family kinases are characterized by the presence of multiple protein-protein interaction domains including a tandem leucine/isoleucine zipper (LZs) motif. Leucine zippers are known to mediate protein dimerization raising the possibility that the tandem leucine/isoleucine zippers may function as a dimerization motif of MLK-3 (1). MLK-3 has several interesting structural features including an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. (2). HPK1 has been found to phosphorylate MLK-3 activation loop in vitro, and Ser281 was found to be the major phosphorylation site, indicating that HPK1 also activates MLK-3 via phosphorylation of the kinase activation loop (3).

Long Name

Mixed Lineage Kinase 3

Alternate Names

MAP3K11, PTK1, RHOE, SPRK

Gene Symbol

MAP3K11

Additional MLK3 Products

Product Documents for MLK3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MLK3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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