MMP-11 Antibody (SN74-08)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-67670

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-67670
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Mouse

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SN74-08

Concentration

1 mg/ml

View all MMP-11 Antibodies »

Product Specifications

Immunogen

Synthetic peptide within Human MMP-11 aa 439-488 / 488. (SwissProt: P24347 Human; SwissProt: Q02853 Mouse; SwissProt: Q499S5 Rat)

Localization

Secreted.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MMP-11 Antibody (SN74-08)

Western Blot: MMP-11 Antibody (SN74-08) [NBP2-67670]

Western Blot: MMP-11 Antibody (SN74-08) [NBP2-67670]

Western Blot: MMP-11 Antibody (SN74-08) [NBP2-67670] - Analysis of MMP11 on 293T cell lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:5,000 dilution was used for 1 hour at room temperature.
Immunocytochemistry/ Immunofluorescence: MMP-11 Antibody (SN74-08) [NBP2-67670]

Immunocytochemistry/ Immunofluorescence: MMP-11 Antibody (SN74-08) [NBP2-67670]

Immunocytochemistry/Immunofluorescence: MMP-11 Antibody (SN74-08) [NBP2-67670] - Staining MMP11 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Immunohistochemistry-Paraffin: MMP-11 Antibody (SN74-08) [NBP2-67670]

Immunohistochemistry-Paraffin: MMP-11 Antibody (SN74-08) [NBP2-67670]

Immunohistochemistry-Paraffin: MMP-11 Antibody (SN74-08) [NBP2-67670] - Analysis of paraffin-embedded mouse spleen tissue using anti-MMP11 antibody. Counter stained with hematoxylin.
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Applications for MMP-11 Antibody (SN74-08)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:500-1:1000

Immunohistochemistry-Paraffin

1:100-1:500

Western Blot

1:500-1:1000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH7.4), 0.05% BSA, 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MMP-11

The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).

Long Name

Matrix Metalloproteinase 11

Alternate Names

MMP11

Gene Symbol

MMP11

Additional MMP-11 Products

Product Documents for MMP-11 Antibody (SN74-08)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MMP-11 Antibody (SN74-08)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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