MMP-17 Antibody (SR3715)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27799

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-27799-100ul
NBP3-27799-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR3715

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MMP-17 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human MMP-17 (Uniprot #: Q9ULZ9)

Specificity

Detects endogenous levels of total MMP-17

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MMP-17 Antibody (SR3715)

Western Blot: MMP-17 Antibody (SR3715) [NBP3-27799] -

Western Blot: MMP-17 Antibody (SR3715) [NBP3-27799] - Western blot analysis of MMP-17 expression in HeLa cell lysate.

Applications for MMP-17 Antibody (SR3715)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MMP-17

Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs. MMP-17 is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A (1). (MMP-17) is expressed mainly in the brain, leukocytes, the colon, the ovary, and the testis. The expression of MMP-17 in leukocytes together with its putative membrane localization suggest that this enzyme could be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators such as tumor necrosis factor-alpha (2). glycosylphospha-tidylinositol (GPI) anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase (3).

Long Name

Matrix Metalloproteinase 17

Alternate Names

MMP17, MT4-MMP

Gene Symbol

MMP17

Additional MMP-17 Products

Product Documents for MMP-17 Antibody (SR3715)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MMP-17 Antibody (SR3715)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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