MMRN2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-83977

Novus Biologicals, part of Bio-Techne
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NBP1-83977
NBP1-83977-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MMRN2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MMRN2 Antibody

Immunocytochemistry/ Immunofluorescence: MMRN2 Antibody [NBP1-83977]

Immunocytochemistry/ Immunofluorescence: MMRN2 Antibody [NBP1-83977]

Immunocytochemistry/Immunofluorescence: MMRN2 Antibody [NBP1-83977] - Staining of human cell line U-2 OS shows localization to vesicles. Antibody staining is shown in green.
MMRN2 Antibody

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] -

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] - Staining of human placenta shows strong cytoplasmic positivity in endothelial cells.
MMRN2 Antibody

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] -

Immunohistochemistry-Paraffin: MMRN2 Antibody [NBP1-83977] - Staining of human testis shows strong cytoplasmic positivity in endothelial cells and nuclear positivity in cells in seminiferous ducts.
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Applications for MMRN2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MMRN2

The MMRN2 gene encodes a 949 amino acid long, 104 kDA multimerin-2 protein that prevents endothelial cells motility. The elastic microfibril interface-located (EMILIN) protein family is an extracellular matrix glycoprotein. Additionally, this protein acts as a negative regulator of angiogenesis by downregulating activation by binding VEGFA. MMRN2 has been linked to adenocarcinoma and skin cancer as it participates in MAPK signaling, PTEN pathway, transendothelial migration of leukocytes, and UPA-UPAR pathway. It has been known to interact with genes VDR, MAPK7, MAP3K3, and DAXX.

Long Name

Multimerin 2

Alternate Names

EMILIN3, Endoglyx-1

Gene Symbol

MMRN2

Additional MMRN2 Products

Product Documents for MMRN2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MMRN2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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