Moesin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90373

Novus Biologicals, part of Bio-Techne
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NBP1-90373
NBP1-90373-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Moesin Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Moesin Antibody

Moesin Antibody

Immunohistochemistry-Paraffin: Moesin Antibody [NBP1-90373] -

Immunohistochemistry-Paraffin: Moesin Antibody [NBP1-90373] -Analysis in human lung and skeletal muscle tissues using NBP1-90373 antibody. Corresponding MSN RNA-seq data are presented for the same tissues.
Western Blot: Moesin Antibody [NBP1-90373]

Western Blot: Moesin Antibody [NBP1-90373]

Western Blot: Moesin Antibody [NBP1-90373] - Analysis using Anti-MSN antibody NBP1-90373 (A) shows similar pattern to independent antibody NBP1-90372 (B).
Immunocytochemistry/ Immunofluorescence: Moesin Antibody [NBP1-90373]

Immunocytochemistry/ Immunofluorescence: Moesin Antibody [NBP1-90373]

Immunocytochemistry/Immunofluorescence: Moesin Antibody [NBP1-90373] - Staining of human cell line U-251 MG shows localization to plasma membrane.
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Applications for Moesin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500-1:1000

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Moesin

Moesin (membrane-organizing extension spike protein) has previously been characterized as a possible receptor protein for heparan sulfate and also as a cytoskeletal linker protein that stabilizes cell surface microvilli, filopodia and lamellipodia. Data indicate that moesin is identical to the 77-kDa band that copurifies with ezrin in its isolation from human placenta (1). Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively (2). It has been demonstrated that ezrin-radixin-moesin proteins are rapidly inactivated after antigen recognition through a Vav1-Rac1 pathway. The resulting disanchoring of the cortical actin cytoskeleton from the plasma membrane decreased cellular rigidity, leading to more efficient T cell-antigen-presenting cell conjugate formation (3).

Alternate Names

Membrane-organizing extension spike protein, moesin

Gene Symbol

MSN

Additional Moesin Products

Product Documents for Moesin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Moesin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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