Mouse Coagulation Factor VII Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB3305
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Ala42-Leu446
Accession # P70375
Specificity
Clonality
Host
Isotype
Applications for Mouse Coagulation Factor VII Antibody
Immunoprecipitation
Sample: Conditioned cell culture medium spiked with Recombinant Mouse Coagulation Factor VII (Catalog # 3305-SE), see our available Western blot detection antibodies
Western Blot
Sample: Recombinant Mouse Coagulation Factor VII (Catalog # 3305-SE)
Formulation, Preparation, and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Coagulation Factor VII
Coagulation Factors VII and VIIa refer to the pro and active forms of the same protease, respectively (1). Factor VII is synthesized in the liver and circulates in the plasma where it binds to tissue factor (TF), an integral membrane protein found in a variety of cell types. Upon binding of TF, factor VII is rapidly converted into VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent functions such as angiogenesis (2). The cleavage and activation of Coagulation Factors VII, IX and X by VIIa:TF is phospholipid-dependent whereas the cleavage of small peptide substrates is not (1). The deduced amino acid sequence of mouse factor VII predicts a signal peptide (residues 1 to 24), propeptide (residues 25 to 41), and the mature chain that can be further processed into the light chain (residues 42 to 193) and the heavy chain (residues 194 to 446). The amino acid sequence of mouse Factor VII is 89%, 71%, 65% and 55% identical to that of rat, human/dog, chimpanzee and chicken.
References
- Morrissey, J.H. (2004) in Handbook of Proteolytic Enzymes, Barrett, A.J. et al. (eds. ), Academic Press, San Diego, p. 1659.
- Versteeg, H.H. et al. (2003) Carcinogenesis 24:1009.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional Coagulation Factor VII Products
Product Documents for Mouse Coagulation Factor VII Antibody
Product Specific Notices for Mouse Coagulation Factor VII Antibody
For research use only