Mouse GFR alpha-like Isoform A Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF5728

R&D Systems, part of Bio-Techne
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Sheep IgG

View all GFR alpha-like Antibodies »

Product Specifications

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant mouse GFR alpha-like isoform A
Gln20-Gly349
Accession # Q6SJE0

Specificity

Detects mouse GFR alpha-like in Western blots. In Western blots, less than 1% cross-reactivity with recombinant mouse (rm) GFR alpha-3 and rmGFR alpha-4 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Mouse GFR alpha-like Isoform A Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant mouse GFR alpha-like
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GFR alpha-like

GFR alpha-like (GDNF receptor-alpha-like) is a predicted 26 and 44 kDa glycoprotein (1) and distant member of the GDNFR family of proteins. It is expressed on both fetal and adult neurons of the CNS, and would appear to function as an anti-apoptotic molecule during neuronal stress. Mature mouse GFR alpha-like is a 374 amino acid (aa) type I transmembrane protein. It contains a 330 aa extracellular region that shows a Gas1 domain (aa 131‑210), and a 23 aa cytoplasmic tail. There is one splice variant that is likely soluble and shows a four aa substitution for aa 235‑393. Over aa 20‑349, mouse GFR alpha-like shares 72% aa identity with human GFR alpha-like.

References

  1. Li, Z. et al. (2005) J. Neurochem. 95:361.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha-like

Alternate Names

GFR alpha like, GFRAL, GRAL

Entrez Gene IDs

389400 (Human); 404194 (Mouse); 501023 (Rat)

Gene Symbol

GFRAL

UniProt

Q6SJE0 (Rat)

Additional GFR alpha-like Products

Product Documents for Mouse GFR alpha-like Isoform A Biotinylated Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Mouse GFR alpha-like Isoform A Biotinylated Antibody

For research use only

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