Mouse Integrin alpha2b/CD41 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB4118
Key Product Details
Species Reactivity
Mouse
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Rat IgG2A Clone # 386627
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin alpha2b/CD41
Leu32-Arg988
Accession # NP_034705
Leu32-Arg988
Accession # NP_034705
Specificity
Detects mouse Integrin alpha2b/CD41 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant mouse Integrin alpha3, -4, -5, -8, -9, or -11.
Clonality
Monoclonal
Host
Rat
Isotype
IgG2A
Applications for Mouse Integrin alpha2b/CD41 Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Mouse Integrin alpha2b/CD41
Sample: Recombinant Mouse Integrin alpha2b/CD41
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Integrin alpha 2b/CD41
Integrin alpha2b (ITGA2b) also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha2b associates with Integrin beta3 to form complexes that interact with fibrinogen, von Willebrand factor, fibronectin, and vitronectin. Integrin alpha2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, mouse Integrin alpha2b shares 81% and 89% amino acid sequence identity with human and rat Integrin alpha2b, respectively.
Alternate Names
CD41, GP2B, GPIIb, GTA, HPA3, ITGA2b
Gene Symbol
ITGA2B
UniProt
Additional Integrin alpha 2b/CD41 Products
Product Documents for Mouse Integrin alpha2b/CD41 Antibody
Product Specific Notices for Mouse Integrin alpha2b/CD41 Antibody
For research use only
Loading...
Loading...
Loading...
Loading...