MTA2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76748

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all MTA2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid peptide near the carboxy terminus of human PID. The immunogen is located within the last 50 amino acids of PID. Amino Acid Squence: PAPSHPASTNEPIVLED

Specificity

PID antibody is predicted to not cross-react with MTA2

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MTA2 Antibody - BSA Free

Western Blot: MTA2 AntibodyBSA Free [NBP1-76748]

Western Blot: MTA2 AntibodyBSA Free [NBP1-76748]

Western Blot: MTA2 Antibody [NBP1-76748] - Western blot analysis of PID/MTA2 expression in HeLa whole cell lysates in the absence (A) or presence (B) of blocking peptide with anti-PID using IMG-5602 at 1 ug /ml.
Immunocytochemistry/ Immunofluorescence: MTA2 Antibody - BSA Free [NBP1-76748]

Immunocytochemistry/ Immunofluorescence: MTA2 Antibody - BSA Free [NBP1-76748]

Immunocytochemistry/Immunofluorescence: MTA2 Antibody [NBP1-76748] - Immunofluorescence of PID in HeLa cells with PID antibody at 10 ug/mL.
Immunohistochemistry: MTA2 Antibody - BSA Free [NBP1-76748]

Immunohistochemistry: MTA2 Antibody - BSA Free [NBP1-76748]

Immunohistochemistry: MTA2 Antibody [NBP1-76748] - Analysis of PID in human small intestine tissue with PID antibody at 2.5 ug/ml.
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Applications for MTA2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MTA2

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.

Alternate Names

DKFZp686F2281, metastasis associated 1 family, member 2, metastasis -associated gene 1-like 1, metastasis associated gene family, member 2, Metastasis-associated 1-like 1, metastasis-associated protein 2, metastasis-associated protein MTA2, MTA1-L1 protein, MTA1L1MTA1-L1, p53 target protein in deacetylase complex, PID

Gene Symbol

MTA2

UniProt

AAG02241 (Human)

Additional MTA2 Products

Product Documents for MTA2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MTA2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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