Mucolipin 1 Antibody
Novus Biologicals, part of Bio-Techne | Catalog # NBP1-92152
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human
Applications
Validated:
Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated, Western Blot
Cited:
Flow Cytometry, Knockdown Validated, Western Blot
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: DTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSE
Reactivity Notes
Mouse 87%, Rat 85%
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for Mucolipin 1 Antibody
![Western Blot: Mucolipin 1 Antibody [NBP1-92152]](https://resources.bio-techne.com/images/products/Mucolipin-1-Antibody-Western-Blot-NBP1-92152-img0011.jpg "Western Blot: Mucolipin 1 Antibody [NBP1-92152]")
Western Blot: Mucolipin 1 Antibody [NBP1-92152]
Western Blot: Mucolipin 1 Antibody [NBP1-92152] - Analysis in human cell line PC-3.![Immunocytochemistry/ Immunofluorescence: Mucolipin 1 Antibody [NBP1-92152]](https://resources.bio-techne.com/images/products/Mucolipin-1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-92152-img0010.jpg "Immunocytochemistry/ Immunofluorescence: Mucolipin 1 Antibody [NBP1-92152]")
Immunocytochemistry/ Immunofluorescence: Mucolipin 1 Antibody [NBP1-92152]
Immunocytochemistry/Immunofluorescence: Mucolipin 1 Antibody [NBP1-92152] - Staining of human cell line U-2 OS shows localization to plasma membrane & cytosol. Antibody staining is shown in green.Applications for Mucolipin 1 Antibody
Application
Recommended Usage
Flow Cytometry
Reported in scientific literature (PMID:31950548).
Immunocytochemistry/ Immunofluorescence
0.25-2 ug/ml
Knockdown Validated
Reported in scientific literature ((PMID: 31950548)
Western Blot
0.04-0.4 ug/ml
Application Notes
ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Formulation, Preparation, and Storage
Purification
Immunogen affinity purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: Mucolipin 1
Defects in MCOLN1 are known to cause mucolipidosis type IV (MLIV), also known as sialolipidosis. MLIV is an autosomal recessive lysosomal storage disorder characterized by severe psychomotor retardation and ophthalmologic abnormalities, including corneal opacity, retinal degeneration and strabismus. Storage bodies of lipids and water-soluble substances are seen by electron microscopy in almost every cell type of the patients. Most patients are unable to speak or walk independently and reach a maximal developmental level of 1-2 years. All patients have constitutive achlorhydia associated with a secondary elevation of serum gastrin levels.
Long Name
Mucolipin-1
Alternate Names
MCOLN1, MG-2, ML1, ML4, MSTP080, Mucolipidin, TRPML1
Gene Symbol
MCOLN1
Additional Mucolipin 1 Products
Product Documents for Mucolipin 1 Antibody
Product Specific Notices for Mucolipin 1 Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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