Muscleblind-like 1 Antibody (S02-4E4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19991

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19991-100ul
NBP3-19991-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-4E4

Concentration

0.3 mg/ml

View all Muscleblind-like 1 Antibodies »

Product Summary for Muscleblind-like 1 Antibody (S02-4E4)

Immunogen

A synthetic peptide of human Muscleblind-like 1 (Uniprot # Q9NR56)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

42 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Muscleblind-like 1 Antibody (S02-4E4)

Western Blot: Muscleblind-like 1 Antibody (S02-4E4) [NBP3-19991]

Western Blot: Muscleblind-like 1 Antibody (S02-4E4) [NBP3-19991]

Western Blot: Muscleblind-like 1 Antibody (S02-4E4) [NBP3-19991] - Western blot detection of Muscleblind-like 1 in A549, HL-60, U251 cell lysates using NBP3-19991 (1:1000 diluted). Predicted band size: 42kDa. Observed band size: 42kDa.

Applications for Muscleblind-like 1 Antibody (S02-4E4)

Application
Recommended Usage

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Muscleblind-like 1

Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.

Alternate Names

DKFZp686P06174, EXP40, EXP42, EXPKIAA0428EXP35, MBNL, muscleblind (Drosophila)-like, muscleblind-like (Drosophila), muscleblind-like protein 1, Triplet-expansion RNA-binding protein

Gene Symbol

MBNL1

Additional Muscleblind-like 1 Products

Product Documents for Muscleblind-like 1 Antibody (S02-4E4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Muscleblind-like 1 Antibody (S02-4E4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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