NANOS1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27084

Novus Biologicals, part of Bio-Techne
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NBP2-27084
NBP2-27084SS
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Key Product Details

Species Reactivity

Human, Primate

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Nanos1 Antibodies »

Product Specifications

Immunogen

Partial synthetic peptide between amino acids 50-100 of human NANOS1.

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human and chimpanzee.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NANOS1 Antibody

Immunohistochemistry-Paraffin: NANOS1 Antibody [NBP2-27084]

Immunohistochemistry-Paraffin: NANOS1 Antibody [NBP2-27084]

Immunohistochemistry-Paraffin: NANOS1 Antibody [NBP2-27084] - analysis of NANOS1 in formalin-fixed, paraffin-embedded human brain tissue using this antibody at 5 ug/ml.

Applications for NANOS1 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nanos1

NANOS1 is a protein that belongs to the nanos family. The C terminus contains a conserved RNA-binding domain that consists of two zinc fingers. Nanos-type zinc finger is composed of two C2HC motifs, each motif binds one molecule of zinc. It is essential for the translation repression activity of the protein. The zinc finger region of NANOS1 shares 62% identity with the zinc finger region of Drosophila Nanos. It is required for the development of germ stem cells in both the sexes. It may regulate translation of specific mRNAs by forming a complex with PUM2. A region of PUM2 that include the RNA-binding domain and 155 upstream amino acids interacted with the zinc finger domain of NANOS1. NANOS1 is expressed during meiosis in spermatocytes but is absent in late post meiotic-stage germ cells. Northern blot analysis shows its almost exclusive expression on testis. It is also expressed in fetal testis and fetal ovary. It is essential for both establishing and maintaining germline stem cells by preventing their precocious entry into oogenesis. Removing NANOS from germline stem cells or their precursors, the primordial germ cells, causes both cell types to differentiate into germline cysts.

Long Name

Nanos Homolog 1

Alternate Names

EC_Rep1a, NOS-1

Gene Symbol

NANOS1

Additional Nanos1 Products

Product Documents for NANOS1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NANOS1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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