NEDL2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-92174

Novus Biologicals, part of Bio-Techne
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NBP1-92174
NBP1-92174-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NEDL2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: TATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLP

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (86%), Rat (85%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NEDL2 Antibody

Immunohistochemistry-Paraffin: NEDL2 Antibody [NBP1-92174]

Immunohistochemistry-Paraffin: NEDL2 Antibody [NBP1-92174]

Immunohistochemistry-Paraffin: NEDL2 Antibody [NBP1-92174] - Analysis in human cerebral cortex and duodenum tissues. Corresponding HECW2 RNA-seq data are presented for the same tissues.
Immunocytochemistry/ Immunofluorescence: NEDL2 Antibody [NBP1-92174]

Immunocytochemistry/ Immunofluorescence: NEDL2 Antibody [NBP1-92174]

Immunocytochemistry/Immunofluorescence: NEDL2 Antibody [NBP1-92174] - Staining of human cell line A-431 shows localization to endoplasmic reticulum.
Immunohistochemistry-Paraffin: NEDL2 Antibody [NBP1-92174]

Immunohistochemistry-Paraffin: NEDL2 Antibody [NBP1-92174]

Immunohistochemistry-Paraffin: NEDL2 Antibody [NBP1-92174] - Staining of human testis shows moderate cytoplasmic positivity in Leydig cells.
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Applications for NEDL2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NEDL2

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhanceactivation of transcription by TP73

Alternate Names

C2 and WW domain-containing protein 2, DKFZp686M17164, EC 6.3.2, EC 6.3.2.-, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, NEDD4-like E3 ubiquitin-protein ligase 2

Gene Symbol

HECW2

Additional NEDL2 Products

Product Documents for NEDL2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for NEDL2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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