Neuregulin-1/NRG1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14417

Novus Biologicals, part of Bio-Techne
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NBP3-14417
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Monkey (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all Neuregulin-1/NRG1 Antibodies »

Product Specifications

Immunogen

Synthetic 17 amino acid peptide from internal region of human Neuregulin-1/NRG1.

Epitope

Internal

Reactivity Notes

Expected reactivity based on percent sequence identity: Mouse, Rat, Hamster, Bat, Equine, Porcine (82%)

Specificity

Human Neuregulin-1/NRG1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Neuregulin-1/NRG1 Antibody

Immunohistochemistry-Paraffin: Neuregulin-1/NRG1 Antibody [NBP3-14417]

Immunohistochemistry-Paraffin: Neuregulin-1/NRG1 Antibody [NBP3-14417]

Immunohistochemistry-Paraffin: Neuregulin-1/NRG1 Antibody [NBP3-14417] - Immunohistochemistry of formalin-fixed, paraffin-embedded human skeletal muscle after heat-induced antigen retrieval.

Applications for Neuregulin-1/NRG1 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Neuregulin-1/NRG1

Neuregulin 1 (NRG1, isoform HRG-beta2) belongs to the neuregulin/heregulin cytokine family consisting of variants of the four genes NRG1, NRG2, NRG3 and NRG4. More than 15 transmembrane and secreted protein isoforms exist for NRG1, they are generated by alternative promoter usage and mRNA splicing. The different isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. The EGF-like domain interacts with ErbB3 and ErbB4 tyrosine kinase receptors, resulting in tyrosine phosphorylation and NRG1 signaling. NRG proteins show distinct spatial and temporal expression patterns. These proteins are important for the development of the nervous system and the heart and in the regulation of neurotransmission.

Alternate Names

Heregulin-1, HGL, HRG1-alpha, HRG1-beta 1, Neuregulin1, NRG1

Gene Symbol

NRG1

Additional Neuregulin-1/NRG1 Products

Product Documents for Neuregulin-1/NRG1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Neuregulin-1/NRG1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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