Neuregulin-3/NRG3 Antibody (S02-9E5)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19721

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19721-100ul
NBP3-19721-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-9E5

Concentration

0.3 mg/ml

View all Neuregulin-3/NRG3 Antibodies »

Product Summary for Neuregulin-3/NRG3 Antibody (S02-9E5)

Immunogen

A synthetic peptide of human Neuregulin-3/NRG3 (Uniprot # P56975)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Neuregulin-3/NRG3 Antibody (S02-9E5)

Western Blot: Neuregulin-3/NRG3 Antibody (S02-9E5) [NBP3-19721]

Western Blot: Neuregulin-3/NRG3 Antibody (S02-9E5) [NBP3-19721]

Western Blot: Neuregulin-3/NRG3 Antibody (S02-9E5) [NBP3-19721] - Western blot detection of Neuregulin-3/NRG3 in K562, Rat Brain lysates using NBP3-19721 (1:1000 diluted). Predicted band size: 78kDa. Observed band size: 55kDa.

Applications for Neuregulin-3/NRG3 Antibody (S02-9E5)

Application
Recommended Usage

Western Blot

1/1000-1/5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Neuregulin-3/NRG3

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Alternate Names

Neuregulin3, NRG3

Gene Symbol

NRG3

Additional Neuregulin-3/NRG3 Products

Product Documents for Neuregulin-3/NRG3 Antibody (S02-9E5)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Neuregulin-3/NRG3 Antibody (S02-9E5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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