Neuronal Pentraxin 2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76899

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Neuronal Pentraxin 2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide near the center of the human NPTX2. The immunogen is located within amino acids 170 - 220 of NPTX2. Amino Acid Squence: LHNETSAHRQKTESTL

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Guinea pig (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

47 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Neuronal Pentraxin 2 Antibody - BSA Free

Western Blot: Neuronal Pentraxin 2 AntibodyBSA Free [NBP1-76899]

Western Blot: Neuronal Pentraxin 2 AntibodyBSA Free [NBP1-76899]

Western Blot: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Independent Antibody Validation (IAV) via Protein Expression Profile in Cell Lines. Loading: 15 ug of lysates per lane. Antibodies: Neuronal Pentraxin 2 NBP1-76899 (2 ug/mL), Neuronal Pentraxin 2 (4 ug/mL), and beta-actin (1 ug/mL), 1h incubation at RT in 5% NFDM/TBST. Secondary: Goat anti-rabbit IgG HRP conjugate at 1:10000 dilution.
Immunohistochemistry-Paraffin: Neuronal Pentraxin 2 Antibody - BSA Free [NBP1-76899]

Immunohistochemistry-Paraffin: Neuronal Pentraxin 2 Antibody - BSA Free [NBP1-76899]

Immunohistochemistry-Paraffin: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Staining of NPTX2 in mouse brain tissue with NPTX2 antibody at 5 ug/ml.
Western Blot: Neuronal Pentraxin 2 AntibodyBSA Free [NBP1-76899]

Western Blot: Neuronal Pentraxin 2 AntibodyBSA Free [NBP1-76899]

Western Blot: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Mouse brain tissue lysate with NPTX2 antibody at (A) 0.5 and (B) 1 ug/mL.
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Applications for Neuronal Pentraxin 2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/mL

Western Blot

0.5-4 ug/mL

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Neuronal Pentraxin 2

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD. This NPTX2 antibody is predicted to be specific to NPTX2 and not recognize NPTX1.

Alternate Names

Apexin, NARP, NPTX2

Gene Symbol

NPTX2

UniProt

NP_002514 (Human)

Additional Neuronal Pentraxin 2 Products

Product Documents for Neuronal Pentraxin 2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Neuronal Pentraxin 2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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