NFKBIL2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48847

Novus Biologicals, part of Bio-Techne
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NBP2-48847
NBP2-48847-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NFKBIL2 Antibodies »

Product Summary for NFKBIL2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: IRVRVQVQDHLFLIPVPHSSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEVLAEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHT

Reactivity Notes

Mouse (84%), Rat (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NFKBIL2 Antibody

Immunocytochemistry/ Immunofluorescence: NFKBIL2 Antibody [NBP2-48847]

Immunocytochemistry/ Immunofluorescence: NFKBIL2 Antibody [NBP2-48847]

Immunocytochemistry/Immunofluorescence: NFKBIL2 Antibody [NBP2-48847] - Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
Immunohistochemistry-Paraffin: NFKBIL2 Antibody [NBP2-48847]

Immunohistochemistry-Paraffin: NFKBIL2 Antibody [NBP2-48847]

Immunohistochemistry-Paraffin: NFKBIL2 Antibody [NBP2-48847] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Applications for NFKBIL2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NFKBIL2

Sharing some sequence similarities with IKBKB, NF-kappa-B inhibitor-like protein 2 (NFKBIL2) belongs to the Tonsoku family. Also known as TONSL, the protein encoded by this gene may bind NF-kappa-B complex and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Additionally, NFKBIL2 is a component of the MMS22L-TONSL complex. Used during DNA replication, this complex is essential for promoting homologous recombination repair of replication fork double strand breaks. NFKBIL2 is known to interact with MMS22L, MCM4, SSRP1, GSK3B and MCM2. Diseases associated with this gene include t-cell leukemia, psoriasis, breast cancer, atherosclerosis, leukemia and immunodeficiency.

Alternate Names

IkappaBR, I-kappa-B-related protein, IKBRFLJ40087, Inhibitor of kappa B-related protein, NF-kappa-B inhibitor-like protein 2, NFKBIL2tonsoku-like protein, Nuclear factor of kappa light polypeptide gene enhancer in B-cellsinhibitor-like 2ikappaBR, tonsoku-like, DNA repair protein

Gene Symbol

TONSL

Additional NFKBIL2 Products

Product Documents for NFKBIL2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NFKBIL2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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