NK1R Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-57675

Novus Biologicals, part of Bio-Techne
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NBP2-57675
NBP2-57675-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NK1R Antibodies »

Product Summary for NK1R Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: FFLLPYINPDLYLKKFIQQVY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NK1R Antibody

Immunohistochemistry-Paraffin: NK1R Antibody [NBP2-57675]

Immunohistochemistry-Paraffin: NK1R Antibody [NBP2-57675]

Immunohistochemistry-Paraffin: NK1R Antibody [NBP2-57675] - Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells in the basal layer.

Applications for NK1R Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NK1R

The Neurokinins, also known as Tachykinins, belong to an evolutionary conserved family of peptide neurotransmitters that share a c-terminal sequence and have an established role in neurotransmission. The mammalian tachykinins include substance P (NK1), neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

Long Name

Neurokinin-1 Receptor

Alternate Names

SPR, TAC1R, TACR1

Gene Symbol

TACR1

Additional NK1R Products

Product Documents for NK1R Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NK1R Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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