NLRP2/NALP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-58146

Novus Biologicals, part of Bio-Techne
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NBP2-58146
NBP2-58146-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NLRP2/NALP2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NLRP2/NALP2 Antibody

Western Blot: NLRP2/NALP2 Antibody [NBP2-58146]

Western Blot: NLRP2/NALP2 Antibody [NBP2-58146]

Western Blot: NLRP2/NALP2 Antibody [NBP2-58146] - Analysis using Anti-NLRP2 antibody NBP2-58146 (A) shows similar pattern to independent antibody NBP1-85553 (B).
Immunocytochemistry/ Immunofluorescence: NLRP2/NALP2 Antibody [NBP2-58146]

Immunocytochemistry/ Immunofluorescence: NLRP2/NALP2 Antibody [NBP2-58146]

Immunocytochemistry/Immunofluorescence: NLRP2/NALP2 Antibody [NBP2-58146] - Staining of human cell line A549 shows localization to cytosol, the Golgi apparatus & vesicles.

Applications for NLRP2/NALP2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Western Blot

0.04-0.4 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP2/NALP2

NLRP2/NALP2, aka PAN1 and PYPAF2, belongs to a cytoplasmic proteins family containing a NACHT domain, leucine rich repeat (NLR) and N-terminal pyrin-containing domain (PYD). As an intracellular pathogen-recognition receptors (PRRs), NLRP2/NALP2 is a 1062 amino acid protein associated in cell responses to apoptotic and inflammatory stimuli. PRRs are key components of immune systems involving in an innate effector mechanisms and activation of adaptive immunity. By interacting with ASC in addition to CARD8 and caspase 1, NLRP2/NALP2 forms an inflammasome functioning as a modulator of NF-kB and procaspase-1 activation in macrophages. Similar to TLRs, activation of the inflammasome by NLRs occurs through the recognition of pathogen-associated molecular patterns (PAMPs) through their LRR domains. NLRP2/NALP2 expressions varies in several human tumor cell lines though the highest were found in MDA-MB-435 and MCF-7 breast cancer, UACC62 melanoma, and Caco2 colon cancer cells.

Long Name

NLR Family, Pyrin Domain Containing 2

Alternate Names

NALP2, NBS1, PAN1, PYPAF2

Gene Symbol

NLRP2

Additional NLRP2/NALP2 Products

Product Documents for NLRP2/NALP2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for NLRP2/NALP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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