Nociceptin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-58314

Novus Biologicals, part of Bio-Techne
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NBP2-58314
NBP2-58314-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Nociceptin Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: RVRSLFQEQEEPEPGMEEAGEMEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Nociceptin Antibody

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314]

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314]

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining in human cerebral cortex and colon tissues using anti-PNOC antibody. Corresponding PNOC RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314]

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314]

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human cerebral cortex, colon, liver and testis using Anti-PNOC anibody NBP2-58314 (A0 shows similar protein distribution tissues o independent antibody.
Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314]

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314]

Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human cerebral cortex shows high expression.
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Applications for Nociceptin Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nociceptin

Nociceptin (Orphanin FQ, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand for the ORL1 receptor. The amino acid sequence of nociceptin hashomology with other opioid peptides, especially the prodynorphin fragment dynorphin A, suggesting a close evolutionary relationship between the precursors. A diffuse distribution throughout the brain is seen with binding studies and in situ hybridization suggesting an extensive role for nociceptin in a multitude of CNS functions. Immunocytochemical localizations in rat spinal cord have demonstrated nociceptin abundance in superficial dorsal horn, lateral spinal nucleus and the region dorsal to the central canal. Nociceptin immunoreactivity was not affected by dorsal rhizotomy, indicating that in spinal cord the peptide is produced by central rather than primary afferent neurons. The localization is supported by its function in processing of nociceptive signals.

Alternate Names

nociceptin, nocistatin, OFQ, P, PPNOC, prepronociceptin, propronociceptin

Gene Symbol

PNOC

Additional Nociceptin Products

Product Documents for Nociceptin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Nociceptin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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