Optineurin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-97837

Novus Biologicals, part of Bio-Techne
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NB100-97837
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all Optineurin Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1 and 50 of human optineurin using the numbering given in entry NP_068815.2 (GeneID 10133).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Optineurin Antibody

Immunoprecipitation: Optineurin Antibody [NB100-97837]

Immunoprecipitation: Optineurin Antibody [NB100-97837]

Immunoprecipitation: Optineurin Antibody [NB100-97837] - Detection of Human Optineurin by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Optineurin antibody NB100-97837 used for IP at 3 mcg/mg lysate. Optineurin was also immunoprecipitated by rabbit anti-Optineurin antibodies NB100-97838 and NB100-97839, which recognize downstream epitopes. Detection: Chemiluminescence with an exposure time of 30 seconds.

Applications for Optineurin Antibody

Application
Recommended Usage

Immunoprecipitation

2 - 5 ug/mg lysate
Application Notes
This antibody is not recommended for Western Blot analysis.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Optineurin

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Alternate Names

ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, OPTN

Entrez Gene IDs

10133 (Human)

Gene Symbol

OPTN

UniProt

NP_068815.2 (Human)

Additional Optineurin Products

Product Documents for Optineurin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Optineurin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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