OS9 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-97288

Novus Biologicals, part of Bio-Techne
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NBP2-97288-100ul
NBP2-97288-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all OS9 Antibodies »

Product Summary for OS9 Antibody

Immunogen

Produced in rabbits immunized with E. coli-derived Human OS9 fragment.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C to 8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for OS9 Antibody

Immunohistochemistry-Paraffin: OS9 Antibody [NBP2-97288]

Immunohistochemistry-Paraffin: OS9 Antibody [NBP2-97288]

Immunohistochemistry-Paraffin: OS9 Antibody [NBP2-97288] - Immunochemical staining of human OS9 in human pancreas with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Immunohistochemistry-Paraffin: OS9 Antibody [NBP2-97288]

Immunohistochemistry-Paraffin: OS9 Antibody [NBP2-97288]

Immunohistochemistry-Paraffin: OS9 Antibody [NBP2-97288] - Immunochemical staining of human OS9 in human placenta with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.

Applications for OS9 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:50-1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

PBS

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: OS9

OS9 is a lectin which functions in endoplasmic reticulum quality control and ER-associated degradation. This ER glycoprotein is found in the intralumenal level and highly expressed in tumor tissue. The OS9 gene is transcriptionally induced upon activation of the Ire1/Xbp1 ER-stress pathway.

Functionally, OS9 binds to HIF-1, a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. It may also bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. One such possible target includes TRPV4.

Alternate Names

Amplified in osteosarcoma 9, endoplasmic reticulum lectin 2, ERLEC2, erlectin 2, OS-9, osteosarcoma amplified 9, endoplasmic reticulum associated protein, osteosarcoma amplified 9, endoplasmic reticulum lectin, protein OS-9

Gene Symbol

OS9

Additional OS9 Products

Product Documents for OS9 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for OS9 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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