Osteoactivin/GPNMB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-69389

Novus Biologicals, part of Bio-Techne
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NBP1-69389
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Osteoactivin/GPNMB Antibodies »

Product Summary for Osteoactivin/GPNMB Antibody

Immunogen

Synthetic peptides corresponding to GPNMB(glycoprotein (transmembrane) nmb) The peptide sequence was selected from the N terminal of GPNMB. Peptide sequence DENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVN. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

60 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Osteoactivin/GPNMB Antibody

Western Blot: Osteoactivin/GPNMB Antibody [NBP1-69389]

Western Blot: Osteoactivin/GPNMB Antibody [NBP1-69389]

Western Blot: Osteoactivin/GPNMB Antibody [NBP1-69389] - This Anti-GPNMB antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 1ug/ml.
Immunohistochemistry: Osteoactivin/GPNMB Antibody [NBP1-69389]

Immunohistochemistry: Osteoactivin/GPNMB Antibody [NBP1-69389]

Immunohistochemistry: Osteoactivin/GPNMB Antibody [NBP1-69389] - Staining of human Lung.

Applications for Osteoactivin/GPNMB Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Osteoactivin/GPNMB

GPNMB is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential.The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Long Name

Glycoprotein Non-Metastatic Melanoma Protein B

Alternate Names

DC-HIL, GPNMB, HGFIN

Gene Symbol

GPNMB

UniProt

A8K7R3 (Human)

Additional Osteoactivin/GPNMB Products

Product Documents for Osteoactivin/GPNMB Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Osteoactivin/GPNMB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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