Oval Cell Marker Antibody (OC2-4E8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-18971

Novus Biologicals, part of Bio-Techne
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NBP1-18971SS
NBP1-18971
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Mouse

Cited:

Mouse

Applications

Validated:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen

Cited:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2B Clone # OC2-4E8

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Oval Cell Marker Antibodies »

Product Specifications

Immunogen

Nonparenchymal cells from DDC-treated mice to induce the oval cell response.

Localization

Cell surface

Specificity

Specific for both proliferating and normal hepatic periductal cells.

Marker

Hepatic periductal cell Marker

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Scientific Data Images for Oval Cell Marker Antibody (OC2-4E8)

Immunohistochemistry: Oval Cell Marker Antibody (OC2-4E8) [NBP1-18971]

Immunohistochemistry: Oval Cell Marker Antibody (OC2-4E8) [NBP1-18971]

Immunohistochemistry: Oval Cell Marker Antibody (OC2-4E8) [NBP1-18971] - Immunohistochemical analysis of DDC treated mouse liver using NBP1-18971.

Applications for Oval Cell Marker Antibody (OC2-4E8)

Application
Recommended Usage

Flow Cytometry

1:50-1:100

Immunocytochemistry/ Immunofluorescence

reported in scientific literature

Immunohistochemistry

1:100

Immunohistochemistry-Frozen

1:100
Application Notes
This Oval Cell Marker (OC2-4E8) antibody is useful for Immunohistochemistry on acetone fixed frozen sections and Flow cytometry.

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Tissue culture supernatant

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Oval Cell Marker

Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.

Additional Oval Cell Marker Products

Product Documents for Oval Cell Marker Antibody (OC2-4E8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Oval Cell Marker Antibody (OC2-4E8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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