p130 [p Thr986] Antibody (S06-9B3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19939

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19939-100ul
NBP3-19939-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-9B3

Concentration

0.3 mg/ml

View all p130 Antibodies »

Product Summary for p130 [p Thr986] Antibody (S06-9B3)

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130 (Uniprot # Q08999)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for p130 [p Thr986] Antibody (S06-9B3)

Western Blot: p130 [p Thr986] Antibody (S06-9B3) [NBP3-19939] - Western blot detection of p130 in K562 cell lysates using NBP3-19939 (1:1000 diluted). Predicted band size: 128kDa. Observed band size: 130kDa.

Applications for p130 [p Thr986] Antibody (S06-9B3)

Application
Recommended Usage

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p130

Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.

Alternate Names

FLJ26459, p130, PRB2, Rb2, RBR-2, retinoblastoma-like 2 (p130), retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein, Retinoblastoma-related protein 2

Gene Symbol

RBL2

Additional p130 Products

Product Documents for p130 [p Thr986] Antibody (S06-9B3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for p130 [p Thr986] Antibody (S06-9B3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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