p130Cas/BCAR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34076

Novus Biologicals, part of Bio-Techne
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NBP2-34076
NBP2-34076-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Rat (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all p130Cas Antibodies »

Product Summary for p130Cas/BCAR1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for p130Cas/BCAR1 Antibody

Western Blot: p130Cas/BCAR1 Antibody [NBP2-34076]

Western Blot: p130Cas/BCAR1 Antibody [NBP2-34076]

Western Blot: p130Cas/BCAR1 Antibody [NBP2-34076] - Analysis in human spleen tissue.
Immunohistochemistry: p130Cas/BCAR1 Antibody [NBP2-34076]

Immunohistochemistry: p130Cas/BCAR1 Antibody [NBP2-34076]

Immunohistochemistry: p130Cas/BCAR1 Antibody [NBP2-34076] - Staining of mouse forebrain shows moderate labelling of cells in the lateral septum
Immunohistochemistry-Paraffin: p130Cas/BCAR1 Antibody [NBP2-34076]

Immunohistochemistry-Paraffin: p130Cas/BCAR1 Antibody [NBP2-34076]

Immunohistochemistry-Paraffin: p130Cas/BCAR1 Antibody [NBP2-34076] - Staining of human cerebellum shows strong cytoplasmic staining in Purkinje cell.
View 3 more images

Applications for p130Cas/BCAR1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p130Cas

BCAR1/p130CAS functions as a scaffolding protein for components of various kinase signaling pathways. It is involved in integrin signaling for cell motility as well as netrin signaling for the guidance of commissural axons. Overexpression of BCAR1/p130CAS has been shown to confer antiestrogen resistance in breast cancer cells. Alternate names for BCAR1/p130CAS include breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, CAS scaffolding protein family member 1, CAS, and CRKAS.

Long Name

Breast Cancer Anti-estrogen Resistance 1

Alternate Names

BCAR1, CASS1, CRKAS

Gene Symbol

BCAR1

UniProt

P56945

Additional p130Cas Products

Product Documents for p130Cas/BCAR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for p130Cas/BCAR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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