P2X7/P2RX7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19654

Novus Biologicals, part of Bio-Techne
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NBP2-19654
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all P2X7/P2RX7 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human P2X7/P2RX7. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Canine (89%), Bovine (85%), Guinea pig (81%).

Localization

Membrane; Multi-pass membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

69 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for P2X7/P2RX7 Antibody

Western Blot: P2X7/P2RX7 Antibody [NBP2-19654]

Western Blot: P2X7/P2RX7 Antibody [NBP2-19654]

Western Blot: P2X7/P2RX7 Antibody [NBP2-19654] - Analysis of lysate from PC3 cells or PC3 cells overexpressing P2X7/P2RX7. Representative images from three independent experiments are shown. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30087439/) licensed under a CC-BY license.
Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP2-19654]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP2-19654]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP2-19654] - Human breast cancer, using P2X7 antibody at 1:500 dilution. Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min.
Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP2-19654]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP2-19654]

Immunohistochemistry-Paraffin: P2X7/P2RX7 Antibody [NBP2-19654] - Mouse brain. P2X7 antibody diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
View 1 more images

Applications for P2X7/P2RX7 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: P2X7/P2RX7

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]

Long Name

P2X Purinergic Receptor 7

Alternate Names

P2RX7

Gene Symbol

P2RX7

Additional P2X7/P2RX7 Products

Product Documents for P2X7/P2RX7 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for P2X7/P2RX7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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