p53R2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76781

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all p53R2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid peptide near the amino terminus of human p53R2. The immunogen is located within the first 50 amino acids of p53R2. Amino Acid Squence: GDPERPEAAGLDQDER

Specificity

At least six isoforms of p53R2 are known to exist; this antibody will detect all but the largest isoform.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for p53R2 Antibody - BSA Free

Western Blot: p53R2 AntibodyBSA Free [NBP1-76781]

Western Blot: p53R2 AntibodyBSA Free [NBP1-76781]

Western Blot: p53R2 Antibody [NBP1-76781] - Analysis of p53R2 in 3T3 cell lysate with p53R2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: p53R2 Antibody - BSA Free [NBP1-76781]

Immunocytochemistry/ Immunofluorescence: p53R2 Antibody - BSA Free [NBP1-76781]

Immunocytochemistry/Immunofluorescence: p53R2 Antibody [NBP1-76781] - Immunofluorescence of p53R2 in Human Lung tissue with p53R2 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: p53R2 Antibody - BSA Free [NBP1-76781]

Immunohistochemistry-Paraffin: p53R2 Antibody - BSA Free [NBP1-76781]

Immunohistochemistry-Paraffin: p53R2 Antibody [NBP1-76781] - Human lung tissue with p53R2 antibody at 1 ug/ml.

Applications for p53R2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

1 ug/ml

Immunohistochemistry-Paraffin

1 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p53R2

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 , Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumour suppression.

Alternate Names

RRM2B

Gene Symbol

RRM2B

UniProt

BAA92434 (Human)

Additional p53R2 Products

Product Documents for p53R2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for p53R2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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