p66 beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56387

Novus Biologicals, part of Bio-Techne
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NB100-56387
NB100-56387SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all p66 beta Antibodies »

Product Summary for p66 beta Antibody

Immunogen

This antibody was developed against a synthetic peptide corresponding to aa 445-460 of mouse p66b.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for p66 beta Antibody

Western Blot: p66 beta Antibody [NB100-56387]

Western Blot: p66 beta Antibody [NB100-56387]

Western Blot: p66 beta Antibody [NB100-56387] - Analysis of p66b in HeLa lysate using this antibody at 4 ug/ml.

Applications for p66 beta Antibody

Application
Recommended Usage

Western Blot

2-4 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p66 beta

Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic genomes (1-3). Increasing evidence indicates that recruitment of histone deacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism of methylated DNA silencing. P66, a zinc finger-containing protein is one of the components of the MeCP1 complex (4). p66 and p68, the two components of MeCP1 are different forms of the same zinc finger-containing protein and are conserved from C.elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 and CR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2 plays an important role in targeting p66 and MBD3 to specific loci (4).

Alternate Names

FLJ37346, GATA zinc finger domain containing 2B, GATA zinc finger domain-containing protein 2B, KIAA1150, MGC138257, MGC138285, p66/p68, P66beta, RP11-216N14.6, transcription repressor p66 beta component of the MeCP1 complex, transcriptional repressor p66-beta

Gene Symbol

GATAD2B

Additional p66 beta Products

Product Documents for p66 beta Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for p66 beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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