PAR3/Thrombin Receptor-like 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-84210

Novus Biologicals, part of Bio-Techne
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NBP2-84210-0.1ml
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all PAR3 Antibodies »

Product Specifications

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PAR3 The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for PAR3/Thrombin Receptor-like 2 Antibody

Western Blot: PAR3/Thrombin Receptor-like 2 Antibody [NBP2-84210]

Western Blot: PAR3/Thrombin Receptor-like 2 Antibody [NBP2-84210]

Western Blot: PAR3/Thrombin Receptor-like 2 Antibody [NBP2-84210] - Host: Rabbit. Target Name: PAR3. Sample Tissue: Human Ovary Tumor lysates. Antibody Dilution: 1ug/ml

Applications for PAR3/Thrombin Receptor-like 2 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PAR3

PAR3, also known as F2RL2 and Coagulation Factor II (Thrombin) Receptor-like 2, is a member of the Protease-activated Receptor (PAR) family of seven transmembrane G protein-coupled receptors that are activated by proteolysis. It is 374 amino acids (aa) in length with a predicted molecular weight of 42.5 kDa. Human PAR3 shares 72% aa sequence identity with the mouse and rat orthologs. PAR3 is highly expressed in the megakaryocytes of the bone marrow. It is also expressed, but in lower levels, in mature megakaryocytes, vascular endothelial and smooth muscle cells, platelets, and in a variety of other tissues such as heart and small intestines. PAR3 plays an essential role in hemostasis and thrombosis. Thrombin, a coagulation protease that activates platelets, binds to and cleaves the N-terminal extracellular domain of PAR3 to generate a new N-terminus. This new N-terminus then functions as a tethered peptide ligand that binds to the receptor. Interestingly, it appears the PAR3 is unable to mediate signaling responses to Thrombin. Instead, it seems to act as a cofactor for two other PAR family members, PAR1 and PAR4.

Long Name

Protease-Activated Receptor 3

Alternate Names

F2RL2, Protease-activated receptor 3, Thrombin Receptor-Like 2

Gene Symbol

F2RL2

Additional PAR3 Products

Product Documents for PAR3/Thrombin Receptor-like 2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PAR3/Thrombin Receptor-like 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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