PAX genes encode nuclear transcription factors which are regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters® anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.

Long Name

Paired Box Gene 6

Alternate Names

keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6

Gene Symbol

PAX6

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Product Documents for Pax6 Antibody (PAX6/8578R) [Janelia Fluor® 525]

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Product Specific Notices for Pax6 Antibody (PAX6/8578R) [Janelia Fluor® 525]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Pax6 Antibody (PAX6/8578R) [Janelia Fluor® 525]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20940JF525

Key Product Details

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Applications for Pax6 Antibody (PAX6/8578R) [Janelia Fluor® 525]

Immunohistochemistry-Paraffin

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Background: Pax6