PDE8A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12247

Novus Biologicals, part of Bio-Techne
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NBP3-12247
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Bovine, Primate

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PDE8A Antibodies »

Product Specifications

Immunogen

Synthetic cyclic peptide from near the N terminus common to all PDE8A variants.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for PDE8A Antibody

Western Blot: PDE8A Antibody [NBP3-12247]

Western Blot: PDE8A Antibody [NBP3-12247]

Western Blot: PDE8A Antibody [NBP3-12247] - WB of NBP3-12247. 1:500 antibody dilution in DiluObuffer.
Immunohistochemistry-Paraffin: PDE8A Antibody [NBP3-12247]

Immunohistochemistry-Paraffin: PDE8A Antibody [NBP3-12247]

Immunohistochemistry-Paraffin: PDE8A Antibody [NBP3-12247] - IHC of NBP3-12247 with human ovarian medulla tissue. 1:200 antibody dilution.
Western Blot: PDE8A Antibody [NBP3-12247]

Western Blot: PDE8A Antibody [NBP3-12247]

Western Blot: PDE8A Antibody [NBP3-12247] - WB of NBP3-12247 with rat heart tissue. 50 ug tissue homogenate loaded in lane. 1:500 antibody dilution in DiluObuffer.

Applications for PDE8A Antibody

Application
Recommended Usage

ELISA

1:10000

Immunocytochemistry/ Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

Background: PDE8A

Phosphodiesterase type 8 (PDE8) is one of the many phosphodiesterases that compartmentalize and hydrolyze cAMP into AMP. The cAMP-specific PDE8 family is comprised of 2 genes (PDE8A and PDE8B) each with multiple splice variants generated by RNA splicing and use of alternate initiation sites. PDE8 family is a high affinity cAMP-specific, IBMX sensitive PDE. PDE8 has a significant conserved region of about 270 amino acids common to all PDEs at the carboxy terminal apparently serves as the catalytic domain. The amino-terminal region of this protein is divergent and presumably accounts for the distinctive and regulatory properties unique to the individual PDE families. PDE8A protein showed significant homology to other cAMP-dependent PDEs (23%) within the catalytic domain. PDE8A is widely expressed in various tissues in contrast to PDE8B that is exclusively expressed in thyroid gland. The PDE8A transcripts are found in brain, pancreas, placenta, thyroid, spleen, trachea, prostate, and uterus.

Long Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Alternate Names

cAMP-specific cyclic nucleotide phosphodiesterase 8A, EC 3.1.4.17, FLJ16150, high affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8A, high-affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8A, HsT19550, phosphodiesterase 8A

Gene Symbol

PDE8A

Additional PDE8A Products

Product Documents for PDE8A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PDE8A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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