PDE8B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB110-40459

Novus Biologicals, part of Bio-Techne
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NB110-40459
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Key Product Details

Species Reactivity

Validated:

Human, Monkey, Primate

Predicted:

Canine (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.3 mg/ml

View all PDE8B Antibodies »

Product Specifications

Immunogen

Synthetic 16 amino acid peptide from internal region of human PDE8B.

Epitope

internal domain of human

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Mouse (88%), Rat (88%), Bat (88%), Porcine (88%), Opossum (81%).

Specificity

Human PDE8B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for PDE8B Antibody

Immunohistochemistry-Paraffin: PDE8B Antibody [NB110-40459]

Immunohistochemistry-Paraffin: PDE8B Antibody [NB110-40459]

Immunohistochemistry-Paraffin: PDE8B Antibody [NB110-40459] - Analysis of anti-PDE8B antibody with human thyroid at concentration 5 ug/ml.

Applications for PDE8B Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: PDE8B

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families. PDE8B exhibits cAMP PDE activity which was not inhibited by various PDE inhibitors, including IBMX. The cAMP hydrolytic activity was unaffected by cGMP, and no cGMP PDE hydrolysis has been detected. Northern blot analysis indicated that the 4.2-kb PDE8B mRNA was expressed at the highest levels in thyroid, and at lower levels in brain, spinal cord, and placenta.

Long Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Alternate Names

HsPDE8B, PIG22

Entrez Gene IDs

8622 (Human)

Gene Symbol

PDE8B

Additional PDE8B Products

Product Documents for PDE8B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PDE8B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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