PFKFB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-84216

Novus Biologicals, part of Bio-Techne
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NBP2-84216-0.1ml
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all PFKFB1 Antibodies »

Product Specifications

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of PFKFB1. Peptide sequence: CPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDT The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for PFKFB1 Antibody

Western Blot: PFKFB1 Antibody [NBP2-84216]

Western Blot: PFKFB1 Antibody [NBP2-84216]

Western Blot: PFKFB1 Antibody [NBP2-84216] - WB Suggested Anti-PFKFB1 Antibody. Titration: 1.0 ug/ml. Positive Control: THP-1 Whole Cell

Applications for PFKFB1 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PFKFB1

Phosphofructokinases (PFK) are regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2), and ADP. Human PFK-1 is tetrameric and isoenzymes include, PFK-1 muscle (PFKM, PFK-A), PFK-1 liver (PFKL, PFK-B), and PFK-1 platelet (PFKP, PFK-C, PFKF). PFK-1 is inhibited by ATP and citrate (from the tricarboxylic acid cycle). PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose-2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose-2,6-bisphosphate, and contains fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).

Alternate Names

2-kinase:fructose-2,6-bisphosphatase, 6PF-2-K/Fru-2,6-P2ase liver isozyme, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, F6PK, fructose-6-phosphate, MGC116715,6PF-2-K/Fru-2,6-P2ase 1, MGC116717, PFK/FBPase 1, PFRXHL2K

Gene Symbol

PFKFB1

Additional PFKFB1 Products

Product Documents for PFKFB1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PFKFB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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