PI 3-Kinase C2 beta Antibody (OTI3B1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46402

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI3B1

Concentration

1 mg/ml

View all PI 3-Kinase C2 beta Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human PIK3C2B(NP_002637) produced in HEK293T cell.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for PI 3-Kinase C2 beta Antibody (OTI3B1)

Western Blot: PI 3-Kinase C2 beta Antibody (OTI3B1) [NBP2-46402]

Western Blot: PI 3-Kinase C2 beta Antibody (OTI3B1) [NBP2-46402]

Western Blot: PI 3-Kinase C2 beta Antibody (3B1) [NBP2-46402] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PI 3-Kinase C2 beta.
Immunohistochemistry: PI 3-Kinase C2 beta Antibody (OTI3B1) [NBP2-46402]

Immunohistochemistry: PI 3-Kinase C2 beta Antibody (OTI3B1) [NBP2-46402]

Immunohistochemistry: PI 3-Kinase C2 beta Antibody (3B1) [NBP2-46402] - Analysis of Human liver tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
Immunohistochemistry: PI 3-Kinase C2 beta Antibody (OTI3B1) [NBP2-46402]

Immunohistochemistry: PI 3-Kinase C2 beta Antibody (OTI3B1) [NBP2-46402]

Immunohistochemistry: PI 3-Kinase C2 beta Antibody (3B1) [NBP2-46402] - Analysis of Adenocarcinoma of Human breast tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Applications for PI 3-Kinase C2 beta Antibody (OTI3B1)

Application
Recommended Usage

Immunohistochemistry

1:150

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PI 3-Kinase C2 beta

PIK3C2B is encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Long Name

Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-containing Subunit beta

Alternate Names

C2-PI3K, Phosphoinositide 3-kinase-C2-beta, PI 3Kinase C2 beta, PIK3C2B, PTDINS-3-kinase C2 beta

Gene Symbol

PIK3C2B

Additional PI 3-Kinase C2 beta Products

Product Documents for PI 3-Kinase C2 beta Antibody (OTI3B1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PI 3-Kinase C2 beta Antibody (OTI3B1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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