PKC iota Antibody (PRKCI/4911) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14155JF646

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Canine, Feline

Applications

Immunohistochemistry-Paraffin, Protein Array

Label

Janelia Fluor 646

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # PRKCI/4911

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PKC iota Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa100-300) of human PKC iota protein (exact sequence is proprietary) (Uniprot: P41743)

Reactivity Notes

0

Localization

Cytoplasm, Cell Membrane, Nucleus

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for PKC iota Antibody (PRKCI/4911) [Janelia Fluor® 646]

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Protein Array

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PKC iota

PKC iota encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Long Name

Protein kinase C iota type

Alternate Names

aPKC-lambda/iota, DXS1179E, nPKC-iota, PRKC-lambda/iota

Gene Symbol

PRKCI

Additional PKC iota Products

Product Documents for PKC iota Antibody (PRKCI/4911) [Janelia Fluor® 646]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PKC iota Antibody (PRKCI/4911) [Janelia Fluor® 646]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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