PLA2G4C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85480

Novus Biologicals, part of Bio-Techne
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NBP1-85480
NBP1-85480-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PLA2G4C Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: EAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PLA2G4C Antibody

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480]

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480]

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480] - Staining of human prostate shows strong membranous and cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480]

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480]

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neurons.
Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480]

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480]

Immunohistochemistry-Paraffin: PLA2G4C Antibody [NBP1-85480] - Staining of human endometrium shows strong cytoplasmic positivity in glandular cells.
View 1 more images

Applications for PLA2G4C Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

Reported in scientific literature (PMID: 29709018)
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PLA2G4C

PLA2G4C, also known as Cytosolic phospholipase A2 gamma, has 3 isoforms, a 541 amino acid isoform that is 61 kDa, a 527 amino acid isoform that is 59 kDa and a 551 amino acid isoform that is 62 kDa; highly expressed in heart and skeletal muscle; hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules has been shown to be a calcium-independent and membrane bound enzyme, and has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid. This protein has being studied for its involvement in oligodendroglioma, ovarian cancer, breast cancer, schizophrenia, and neuronitis. PLA2G4C protein has been observed with relation to S100A10, MBOAT2, GPCPD1, LPCAT1, and LPCAT2 in immune response CD16 signaling in NK cells, development Leptin signaling via JAK/STAT and MAPK cascades, development Alpha-2 adrenergic receptor activation of ERK, immune response CCR3 signaling in eosinophils, neurophysiological process PGE2-induced pain processing, chemokine signaling, DHA signaling, VEGF family ligands and receptor interactions, antioxidant action of vitamin-C, LDL oxidation in atherogenesis, phospholipases, acyl chain remodelling of PE, metabolism, acyl chain remodelling of PC, hydrolysis of LPC, and phospholipid metabolism pathways.

Alternate Names

CPLA2-gamma, cytosolic phospholipase A2 gamma, DKFZp586C0423, EC 3.1.1.4, FLJ42247, FLJ44164, Phospholipase A2 group IVC, phospholipase A2, group IVC (cytosolic, calcium-independent)

Gene Symbol

PLA2G4C

Additional PLA2G4C Products

Product Documents for PLA2G4C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PLA2G4C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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