Plasminogen Antibody (5H3)

Novus Biologicals, part of Bio-Techne | Catalog # NB110-7926

Novus Biologicals, part of Bio-Techne
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NB110-7926
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 5H3

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Plasminogen Antibodies »

Product Specifications

Immunogen

Hybridoma clone has been derived from hybridization of X63.Ag8.653 myeloma cells with spleen cells of Balb/c mice immunized with purified human plasminogen.

Localization

Secreted

Specificity

Reacts with plasminogen, plasmin and angiostatin. No cross-reactivity with other human serum proteins.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Plasminogen Antibody (5H3)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Sandwich ELISA

1:100-1:2000
Application Notes
Recommended pairs for sandwich immunoassay (capture-detection): NB110-7926 - NB120-10176

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS (pH 7.4)

Preservative

0.09% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Plasminogen

Plasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 to 200mg/l. Plasminogen is activated by tissue plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen.

Alternate Names

Plg

Entrez Gene IDs

5340 (Human)

Gene Symbol

PLG

Additional Plasminogen Products

Product Documents for Plasminogen Antibody (5H3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Plasminogen Antibody (5H3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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