PLC-gamma 1 Antibody (S01-6B4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20073

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-20073-100ul
NBP3-20073-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S01-6B4

Concentration

0.3 mg/ml

View all PLC-gamma 1 Antibodies »

Product Summary for PLC-gamma 1 Antibody (S01-6B4)

Immunogen

A synthetic peptide of human PLC-gamma 1 (Uniprot # P19174)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PLC-gamma 1 Antibody (S01-6B4)

Western Blot: PLC-gamma 1 Antibody (S01-6B4) [NBP3-20073]

Western Blot: PLC-gamma 1 Antibody (S01-6B4) [NBP3-20073]

Western Blot: PLC-gamma 1 Antibody (S01-6B4) [NBP3-20073] - Western blot detection of PLC-gamma 1 in U2OS, C6 using NBP3-20073 (1:1000 diluted)

Applications for PLC-gamma 1 Antibody (S01-6B4)

Application
Recommended Usage

Western Blot

1/2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PLC-gamma 1

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups (1). Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain (2). Also, results indicate a lipase-independent role of PLC-gamma in the physiological agonist-induced activation of Ca2+ entry (3).

Long Name

Phospholipase C gamma 1

Alternate Names

PLCG1, PLCgamma 1, PPLCA

Gene Symbol

PLCG1

Additional PLC-gamma 1 Products

Product Documents for PLC-gamma 1 Antibody (S01-6B4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PLC-gamma 1 Antibody (S01-6B4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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