Polycystin 2 Antibody (4C8)

Novus Biologicals, part of Bio-Techne | Catalog # H00005311-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Proximity Ligation Assay, Sandwich ELISA, Western Blot

Cited:

Proximity Ligation Assay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 4C8

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Polycystin 2 Antibodies »

Product Specifications

Immunogen

PKD2 (NP_000288, 261 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. PVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP

Specificity

PKD2 - polycystic kidney disease 2 (autosomal dominant)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Polycystin 2 Antibody (4C8)

Western Blot: Polycystin 2 Antibody (4C8) [H00005311-M01]

Western Blot: Polycystin 2 Antibody (4C8) [H00005311-M01]

Western Blot: Polycystin 2 Antibody (4C8) [H00005311-M01] - PKD2 monoclonal antibody (M01), clone 4C8. Analysis of PKD2 expression in human liver.
Immunocytochemistry/ Immunofluorescence: Polycystin 2 Antibody (4C8) [H00005311-M01]

Immunocytochemistry/ Immunofluorescence: Polycystin 2 Antibody (4C8) [H00005311-M01]

Immunocytochemistry/Immunofluorescence: Polycystin 2 Antibody (4C8) [H00005311-M01] - Analysis of monoclonal antibody to PKD2 on HeLa cell . Antibody concentration 10 ug/ml.
Sandwich ELISA: Polycystin 2 Antibody (4C8) [H00005311-M01] - Detection limit for recombinant GST tagged PKD2 is approximately 0.3ng/ml as a capture antibody.

Applications for Polycystin 2 Antibody (4C8)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control. Use in PLA reported in secitific publication PMID: 32543276
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Polycystin 2

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

Alternate Names

APKD2, Autosomal dominant polycystic kidney disease type II protein, MGC138466, MGC138468, PC2, Pc-2, PKD4, polycystic kidney disease 2 (autosomal dominant), Polycystic kidney disease 2 protein, polycystin-2, polycystwin, R48321, transient receptor potential cation channel, subfamily P, member 2, TRPP2

Entrez Gene IDs

5311 (Human)

Gene Symbol

PKD2

OMIM

173910 (Human)

UniProt

NP_000288 (Human)

Additional Polycystin 2 Products

Product Documents for Polycystin 2 Antibody (4C8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Polycystin 2 Antibody (4C8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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