PP1 alpha/PPP1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-30764

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Bovine

Applications

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PP1 alpha Antibodies »

Product Specifications

Immunogen

The immunogen used to generate the purified antibody was a peptide conjugated to KLH corresponding to the sequence NH2-Arg-Pro-Ile-Thr-Pro-Pro-Arg-Asn-Ser-AlaLys-Ala-Lys-Lys-COOH. This peptide antibody corresponds to C -terminal peptide of PP1 alpha/PPP1A catalytic subunit having a MW of 38kDa. The sequence used is amino acid 317-330.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PP1 alpha/PPP1A Antibody

PP1 alpha/PPP1A Antibody

Western Blot: PP1 alpha/PPP1A Antibody [NBP3-30764] -

Western Blot: PP1 alpha/PPP1A Antibody [NBP3-30764] - Legend: Novus Biologicals' rabbit anti PP 1 alpha antibody western blot of total rat brain homogenate.(+) indicates staining done in the presence of specific blocking peptide or (-) peptide control. The darkest mark is located at -36-38 kDa.

Applications for PP1 alpha/PPP1A Antibody

Application
Recommended Usage

Western Blot

: 1:500-1:1000
Application Notes
.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

Phosphate buffered saline

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PP1 alpha

Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favouring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3).

Long Name

Protein Phosphatase 1 Catalytic Subunit alpha

Alternate Names

PPP1A, PPP1CA

Gene Symbol

PPP1CA

Additional PP1 alpha Products

Product Documents for PP1 alpha/PPP1A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PP1 alpha/PPP1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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